Catalytic Triad → Outward

ACI radiation from each catalytic residue. Red/orange/blue = high-ACI neighbors. Positions marked with fitness and mutability status.

Select Catalytic Residue

Key Insight

The catalytic triad is surrounded by a conserved, mutationally intolerant shell. Engineering must approach from the periphery via allosteric pathways, not by directly modifying the active site core.

Residue Color Code

YellowCatalytic triad

Path color (ball+stick)High-ACI neighbors

Green sphereMutable (DMS hotspot)

Red sphereIntolerant (coldspot/conserved)

Catalytic Triad

Mutable (fitness > 0, potential target)

Intolerant (conserved, deleterious)

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